FEATURES

FAMILY

DESCRIPTION

Also known as RHSA_DICD3, rhsA. Toxic component of a toxin-immunity protein module, which functions as a cellular contact-dependent growth inhibition (CDI) system. This protein may be a nuclease that is specifically inhibited by its cognate immunity protein RhsAI. Upon expression of the C-terminus (residues 1284-1434) in E.coli growth is inhibited, cells elongate, nucleoids condense and plasmid DNA is degraded; these effects are blocked specifically by cognate immunity protein RshIA. Cell contact is necessary for growth inhibition.

EXTERNAL LINKS

uniprot
enzyme classification

rhsA

Probable deoxyribonuclease RhsA

rhsA

Molecular Synopsis