FEATURES

FAMILY

DESCRIPTION

Also known as DOEA_HALED, doeA. Involved in the biosynthesis of ectoine ((S)-2-methyl-1, 4, 5, 6-tetrahydropyrimidine-4-carboxylic acid) which is a highly soluble organic osmolyte, called compatible solute, use to avoid excessive water efflux, plasmolysis, molecular crowding of the cytoplasm, and cessation of growth in high salinity environments. Catalyzes the hydrolysis of ectoine to N-acetyl-L-2, 4-diaminobutyric acid (N-Ac-DABA). It can produce both isoforms N-gamma-acetyl-L-2, 4-diaminobutyric acid (N-gamma-Ac-DABA) and N-alpha-acetyl-L-2, 4-diaminobutyric acid (-Nalpha-Ac-DABA), however N-alpha-Ac-DABA is the essential substrate for the subsequent catabolic enzyme DoeB.

EXTERNAL LINKS

uniprot
enzyme classification

doeA

Ectoine hydrolase

doeA

Molecular Synopsis