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FEATURES

FAMILY

DESCRIPTION

Also known as NICA_DICPU, ncstn. Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Component of the gamma-secretase complex, a complex composed of a presenilin homodimer, nicastrin, aph1 and pen2.

Also known as NICA_DICPU, ncstn. Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch recep ...

EXTERNAL LINKS

uniprot
enzyme classification

ncstn

Nicastrin

Mutations

Mutation(s) distribution

Mutations table

Search Mutation

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