FEATURES

FAMILY

DESCRIPTION

Also known as TRIO_RAT, Trio. Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases. Involved in coordinating actin remodeling, which is necessary for cell migration and growth (By similarity). Plays a key role in the regulation of neurite outgrowth and lamellipodia formation (By similarity). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (PubMed:26721934). May act as a regulator of adipogenesis (By similarity). Interacts with CARMIL1 (By similarity). Interacts with PTPRF/LAR (By similarity). Interacts with ANKRD26 (By similarity). Interacts with Bassoon/BSN and Piccolo/PCLO (PubMed:27907191). Interacts with the cytoplasmic region of the heterodimer formed by NGFR and SORCS2. ProNGF binding mediates dissociation of TRIO from the receptor complex (By similarity).

EXTERNAL LINKS

Trio

Triple functional domain protein

Trio

Molecular Synopsis