FEATURES

DESCRIPTION

Also known as INADL_RAT, Patj, Cipp, Inadl. Scaffolding protein that facilitates the localization of proteins to the cell membrane (By similarity). Required for the correct formation of tight junctions and epithelial apico-basal polarity (By similarity). Positively regulates epithelial cell microtubule elongation and cell migration, possibly via facilitating localization of PRKCI/aPKC and PAR3D/PAR3 at the leading edge of migrating cells (By similarity). Plays a role in the correct reorientation of the microtubule-organizing center during epithelial migration (By similarity). May regulate the surface expression and/or function of ASIC3 in sensory neurons (By similarity). May recruit ARHGEF18 to apical cell-cell boundaries (By similarity). Forms a ternary complex with PALS1 and CRB1 (By similarity). Component of a complex whose core is composed of ARHGAP17, AMOT, PALS1, INADL/PATJ and PARD3/PAR3 (By similarity). Forms a heterotrimeric complex composed of MMP5, LIN7B and PATJ; the N-terminal L27 domain of PALS1 interacts with the L27 domain of PATJ and the C-terminal L27 domain of PALS1 interacts with the L27 domain of LIN7B (PubMed:22337881). Component of a complex composed of CRB3, PALS1 and PATJ (By similarity). Interacts (via N-terminus) with PALS1/PALS (via PDZ domain) (By similarity). Interacts with TJP3/ZO-3 and CLDN1/claudin-1 (By similarity). Interacts with ASIC3, KCNJ10, KCNJ15, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NLGN2, and HTR2A (By similarity). Interacts with MPP7 (By similarity). Directly interacts with HTR4 (By similarity). Interacts (via PDZ domain 8) with WWC1 (via the ADDV motif) (By similarity). Interacts with SLC6A4 (By similarity). Interacts (via C-terminus) with ARHGEF18 (By similarity). Interacts with NPHP1 (By similarity). Interacts with PARD3/PAR3 (By similarity).

EXTERNAL LINKS

Patj

Structural Ligandability

Domains Chains

Distribution