FEATURES

DESCRIPTION

Also known as MORC3_MOUSE, Morc3, Nxp2, Zcwcc3. Nuclear factor which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism (By similarity). Sumoylated MORC3-NBs can also associate with PML-NBs (By similarity). Recruits TP53 and SP100 to PML-NBs, thus regulating TP53 activity (PubMed:17332504). Binds RNA in vitro (By similarity). Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3 (By similarity). The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0 (By similarity). Homodimer. The sumoylated form interacts with PML (via SUMO-interacting motif). Interacts with PT53.

EXTERNAL LINKS

Morc3

Mutations

Mutation(s) distribution

Mutations table