FEATURES

DESCRIPTION

Also known as AMO1_CHATD, AMO1. Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm). AMO1 is specifically important for nuclear protein and mRNA export. The nuclear pore complex (NPC) constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. The 55-60 MDa NPC is composed of at least 28 different subunits: AMO1, ELYS, GLE1, GLE2, MLP1, NDC1, NIC96, NSP1, NUP133, NUP145, NUP152, NUP159, NUP170, NUP188, NUP192, NUP37, NUP49, NUP53, NUP56, NUP57, NUP82, NUP84, NUP85, POM152, POM33, POM34, SEC13 and SEH1. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof.

EXTERNAL LINKS

AMO1

Nucleoporin AMO1

AMO1

Molecular Synopsis