FEATURES

FAMILY

DESCRIPTION

Also known as ERH_SCHPO, erh1, new10. Forms part of the erh1-mmi1 complex that recruits the CCR4-NOT complex and the NURS complex to target RNAs (PubMed:26942678, PubMed:30651569, PubMed:31974447). Suppresses the meiotic program during vegetative growth and promotes the meiotic program during mating (PubMed:31974447). Recruitment of the NURS complex to target mRNAs promotes mRNA decay by engagement of the nuclear exosome, and formation of heterochromatin islands at meiotic genes silenced by the exosome (PubMed:26942678). Recruitment of the CCR4-NOT complex to target RNAs promotes heterochromatin formation at RNAi-dependent heterochromatin domains (HOODs), including a subset of meiotic genes, lncRNAs and retrotransposons (PubMed:26942678). Recruitment of the CCR4-NOT complex to rDNA promotes rDNA heterochromatin assembly (PubMed:26942678). Homodimer (PubMed:30651569, PubMed:31974447). Component of the erh1-mmi1 complex (PubMed:26942678, PubMed:30651569). Interacts with mmi1 (via N-terminus) in a 2:2 stoichiometry (PubMed:26942678, PubMed:30651569, PubMed:31974447).

EXTERNAL LINKS

erh1

Enhancer of rudimentary homolog 1

erh1

Molecular Synopsis