FEATURES

FAMILY

DESCRIPTION

Also known as FADA5_MYCTU, fadA5. Involved in the beta-oxidation of the cholesterol side chain (PubMed:19822655). It is important for utilization of cholesterol as a sole carbon source in vitro and for full virulence in the chronic stage of mouse lung infection (PubMed:19822655). Catalyzes the thiolysis of 3, 22-dioxochol-4-en-24-oyl-CoA to yield 3-oxo-4-pregnene-20-carboxyl-CoA (3-OPC-CoA) and acetyl-CoA (PubMed:25482540). Also able to use acetoacetyl-CoA (AcAcCoA) as substrate (PubMed:19822655). Dimer of dimers.

EXTERNAL LINKS

uniprot
enzyme classification

fadA5

Steroid 3-ketoacyl-CoA thiolase

fadA5

Molecular Synopsis