FEATURES

FAMILY

DESCRIPTION

Also known as PPEP2_PAEA2, PAV_1c07830. Zinc-dependent endoprotease with a unique preference for proline residues surrounding the scissile bond, which cleaves in a PLP-|-PVP motif. Cleaves the cell surface protein encoded by an adjacent gene, which contains two PPEP-2 cleaving sites and putative extracellular matrix-binding domains. Thereby, may have a role in the regulation of P.alvei adhesion. Is not able to cleave within the PVP-|-PVQ motif, and only shows a very poor cleavage of the VNP-|-PVP motif in vitro, which is the optimal substrate peptide for PPEP-1 from P.difficile. Monomer.

EXTERNAL LINKS

uniprot
enzyme classification

PAV_1c07830

Pro-Pro endopeptidase

PAV_1c07830

Molecular Synopsis