FEATURES

FAMILY

DESCRIPTION

Also known as KIF2A_HUMAN, KIF2A, KIF2, KNS2. Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity. Interacts with AURKA, PSRC1 and PLK1.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

KIF2A

Mutations

Mutation(s) distribution

Mutations table