FEATURES

FAMILY

DESCRIPTION

Also known as MASP2_HUMAN, MASP2. Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase. Homodimer; disulfide-linked. Binds MBL2. Isoform 2 binds to MASP1. Binds SERPING1. Dimerization and MBL2 binding requires calcium ions.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

MASP2

Mannan-binding lectin serine protease 2

MASP2

Molecular Synopsis