FEATURES

FAMILY

DESCRIPTION

Also known as GRM8_HUMAN, GRM8, GPRC1H, MGLUR8. G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Interacts with PICK1.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

GRM8

Metabotropic glutamate receptor 8

GRM8

Molecular Synopsis