FEATURES

FAMILY

DESCRIPTION

Also known as CLIC1_HUMAN, CLIC1, G6, NCC27. Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle. Monomer. Homodimer (in vitro). Interacts with TRAPPC2. Dimerization requires a conformation change that leads to the exposure of a large hydrophobic surface. In vivo, this may lead to membrane insertion. Interacts with AKAP9.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CLIC1

Chloride intracellular channel protein 1

Mutations

Mutation(s) distribution

Mutations table

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