FEATURES

FAMILY

DESCRIPTION

Also known as ST1C2_HUMAN, SULT1C2, SULT1C1. Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation. Sulfonates p-nitrophenol, a small phenolic compond. Does not sulfonate steroids, dopamine, acetaminophen, or alpha-naphthol (PubMed:9852044, PubMed:10783263, PubMed:10481272). Catalyzes the sulfonation of the carcinogenic N-Hydroxy-2-acetylaminofluorene leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis (PubMed:9852044).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

SULT1C2

Sulfotransferase 1C2

SULT1C2

Molecular Synopsis