PDE2A (cGMP-dependent 3', 5'-cyclic phosphodiesterase)

FEATURES

FAMILY

cyclic nucleotide phosphodiesterase family

DESCRIPTION

Also known as PDE2A_HUMAN, PDE2A. Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Plays an important role in growth and invasion of malignant melanoma cells (e.g. pseudomyxoma peritonei (PMP) cell line) (PubMed:24705027)., Regulates mitochondrial cAMP levels and respiration (By similarity). Involved in the regulation of mitochondria morphology/dynamics and apoptotic cell death via local modulation of cAMP/PKA signaling in the mitochondrion, including the monitoring of local cAMP levels at the outer mitochondrial membrane and of PKA-dependent phosphorylation of DNM1L (PubMed:28463107). Homodimer.

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EXTERNAL LINKS

PDE2A

cGMP-dependent 3', 5'-cyclic phosphodiesterase

LIGANDABILITY MUTATIONS

PDE2A

Molecular Synopsis