FEATURES

FAMILY

DESCRIPTION

Also known as PIR_HUMAN, PIR. Transcriptional coregulator of NF-kappa-B which facilitates binding of NF-kappa-B proteins to target kappa-B genes in a redox-state-dependent manner. May be required for efficient terminal myeloid maturation of hematopoietic cells. Has quercetin 2, 3-dioxygenase activity (in vitro). May interact with NF1/CTF1. Interacts with BCL3. Identified in a complex comprised of PIR, BLC3, NFKB1 and target DNA.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PIR

Pirin

PIR

Molecular Synopsis