FEATURES

FAMILY

DESCRIPTION

Also known as BAK_MOUSE, Bak1, Bak. In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti-apoptotic action of BCL2. Homodimer. Formation of the homodimer is zinc-dependent. Forms heterodimers with BCL2 and BCL2L1 isoform Bcl-X(L). Forms heterooligomers with BAX (By similarity). Interacts with BCL2A1 (PubMed:18462686). Interacts withRTL10/BOP (PubMed:18462686). Interacts with VDAC1 (By similarity). Interacts with GIMAP3/IAN4 and GIMAP5/IAN5 (PubMed:16509771).

EXTERNAL LINKS

uniprot
enzyme classification

Bak1

Mutations

Mutation(s) distribution

Mutations table