FEATURES

DESCRIPTION

Also known as GLU2B_MOUSE, Prkcsh. Regulatory subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1, 3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (PubMed:27462106, PubMed:9148925). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (PubMed:21685914). Heterodimer of a catalytic alpha subunit (GANAB) and a beta subunit (PRKCSH) (PubMed:9148925, PubMed:27462106). Binds glycosylated PTPRC (PubMed:9148925).

EXTERNAL LINKS

uniprot
enzyme classification

Prkcsh

Glucosidase 2 subunit beta

Prkcsh

Molecular Synopsis