FEATURES

FAMILY

DESCRIPTION

Also known as MFNG_MOUSE, Mfng. Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1.

EXTERNAL LINKS

uniprot
enzyme classification

Mfng

Beta-1, 3-N-acetylglucosaminyltransferase manic fringe

Mutations

Mutation(s) distribution

Mutations table

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