FEATURES

DESCRIPTION

Also known as NF2IP_MOUSE, Nfatc2ip, Nip45. In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression. Down-regulates formation of poly-SUMO chains by UBE2I/UBC9. Interacts with NFATC2, TRAF1, TRAF2 and PRMT1. Interacts with UBE2I/UBC9.

Also known as NF2IP_MOUSE, Nfatc2ip, Nip45. In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL ...

EXTERNAL LINKS

uniprot
enzyme classification

Nfatc2ip

NFATC2-interacting protein

Nfatc2ip

Molecular Synopsis