FEATURES

FAMILY

DESCRIPTION

Also known as INCEA_XENLA, incenp-a. Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with aurkb/aurora-B, the N-terminus associated with cdca8/borealin and/or cdca9/dasra-A tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs aurkb/aurora-B toward substrates near microtubules. Activates aurkb. Component of the CPC composed of survivin/birc5, incenp, cdca8/borealin and/or cdca9/dasra-A, and aurkb/aurora-B. Interacts (via C-terminus) with aurkb (via N-terminus and kinase domain). Interacts (via N-terminus) with birc5.1, birc5.2, cdca8 and cdca9. Interacts with mtus1.

EXTERNAL LINKS

incenp-a

Inner centromere protein A

incenp-a

Molecular Synopsis