FEATURES

FAMILY

nucleotide pyrophosphatase/phosphodiesterase family

DESCRIPTION

Also known as ENPP3_HUMAN, ENPP3, PDNP3. Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP (PubMed:29717535). Limits mast cell and basophil responses during inflammation and during the chronic phases of allergic responses by eliminating the extracellular ATP that functions as signaling molecule and activates basophils and mast cells and induces the release of inflammatory cytokines. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic cells (By similarity). Has also alkaline phosphodiesterase activity (PubMed:11342463). Monomer and homodimer.

Also known as ENPP3_HUMAN, ENPP3, PDNP3. Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP (PubMed:29717535). Limits mast cell and basophil responses during in ...

EXTERNAL LINKS

ENPP3

Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

ENPP3

Molecular Synopsis