FEATURES

FAMILY

DESCRIPTION

Also known as PAHX_HUMAN, PHYH, PAHX. Catalyzes the 2-hydroxylation of not only racemic phytanoyl-CoA and the isomers of 3-methylhexadecanoyl-CoA, but also a variety of other mono-branched 3-methylacyl-CoA esters (with a chain length of at least seven carbon atoms) and straight-chain acyl-CoA esters (with a chain length longer than four carbon atoms) (PubMed:9326939, PubMed:10744784, PubMed:12031666, PubMed:12923223). Does not hydroxylate long and very long straight chain acyl-CoAs or 2-methyl- and 4-methyl-branched acyl-CoAs (PubMed:10744784, PubMed:12923223). Interacts with FKBP52 (PubMed:10051602). Interacts with PHYHIP.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PHYH

Phytanoyl-CoA dioxygenase, peroxisomal

PHYH

Molecular Synopsis