FEATURES

DESCRIPTION

Also known as TPSN_HUMAN, TAPBP, NGS17, TAPA. Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading). Heterodimer with PDIA3; disulfide-linked. Obligatory mediator for the interaction between newly assembled MHC class I molecules, calreticulin, PDIA3 and TAP. Up to 4 MHC class I/tapasin complexes bind to 1 TAP (PubMed:19119025, PubMed:21263072, PubMed:26611325). Interacts with HLA-G-B2M complex; this interaction is required for loading of high affinity peptides.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

TAPBP

Tapasin

TAPBP

Molecular Synopsis