FEATURES

FAMILY

DESCRIPTION

Also known as RAD50_ARCFU, rad50. Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex. Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.

EXTERNAL LINKS

uniprot
enzyme classification

rad50

DNA double-strand break repair Rad50 ATPase

rad50

Molecular Synopsis