FEATURES

FAMILY

class-V pyridoxal-phosphate-dependent aminotransferase family

DESCRIPTION

Also known as ISCS2_ARCFU, iscS2. Catalyzes the removal of elemental sulfur from cysteine to produce alanine (Probable). Binds 1 2Fe-2S cluster per subunit in a crystal formed under reducing conditions; this subunit provides 1 ligand while IscU provides the other 3 ligands. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.

EXTERNAL LINKS

uniprot
enzyme classification

iscS2

Mutations

Mutation(s) distribution

Mutations table