FEATURES

FAMILY

DESCRIPTION

Also known as SOPB_SALTY, sopB, sigD. Converts phosphatidylinositol 3, 4, 5-trisphosphate (PtdIns 3, 4, 5-P3) to PtdIns 3-P and prevents the transition of PtdIns 3-P to PtdIns 3, 5-P2. It is one of the known effectors injected by Salmonella into the host cell and is required for invasion and for an efficient generation and maintenance of Salmonella-containing vacuole (SVC). Alteration of the phosphoinositide composition of the plasma membrane causes membrane ruffling and actin cytoskeleton rearrangements. The persistence of PtdIns 3-P diverts the SCV from the endocytic pathway resulting in enlarged vesicles, which are essential to create a favorable environment where Salmonella can replicate and avoid immune defenses of the host cell.

EXTERNAL LINKS

sopB

Mutations

Mutation(s) distribution

Mutations table