FEATURES

FAMILY

class-V pyridoxal-phosphate-dependent aminotransferase family

DESCRIPTION

Also known as SUFS_BACSU, sufS, csd, yurW. Enzyme able to deliver sulfur to partners involved in Fe-S cluster assembly. Catalyzes the removal of elemental sulfur atoms from L-cysteine to produce L-alanine. Activity is stimulated 40- to 100-fold by SufU, which acts as a second substrate for this enzyme following release of Ala, and generating SufU.S. A mixture of SufS, SufU, Fra and L-cysteine is able to reconstitute Fe-S clusters on apo-aconitase (citB), reconstituting aconitase activity. Homodimer. Interacts with SufU; the complex is more stable in the presence of L-cysteine. An N-terminal His-tag destabilizes this interaction.

EXTERNAL LINKS

uniprot
enzyme classification

sufS

Cysteine desulfurase SufS

sufS

Molecular Synopsis