FEATURES

FAMILY

DESCRIPTION

Also known as ARK72_HUMAN, AKR7A2, AFAR, AFAR1, AKR7. Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1, 2-naphthoquinone and 9, 10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. Homodimer.

EXTERNAL LINKS

AKR7A2

Aflatoxin B1 aldehyde reductase member 2

AKR7A2

Molecular Synopsis