FEATURES

FAMILY

GEF (guanine exchange factor) SopE family

DESCRIPTION

Also known as SOPE_SALTM, sopE. Activator for both CDC42 and RAC1 by directly engaging these Rho GTPases and acting as potent guanine nucleotide exchange factor (GEF). This activation results in actin cytoskeleton rearrangements and stimulates membrane ruffling, promoting bacterial entry into non-phagocytic cells. Also activates MAPK8, indicating that it is capable of stimulating signaling pathways that can lead to nuclear responses. Chaperone InvB is required for secretion and translocation of SopE.

EXTERNAL LINKS

uniprot
enzyme classification

sopE

Guanine nucleotide exchange factor SopE

sopE

Molecular Synopsis