FEATURES

FAMILY

DESCRIPTION

Also known as RIPA_MYCTU, ripA. Peptidoglycan endopeptidase that cleaves the bond between D-glutamate and meso-diaminopimelate. Binds and degrades high-molecular weight peptidoglycan from a number of Actinobacteria; activity is increased in the presence of RpfB and inhibited by PBP1A (ponA1). Required for normal separation of daughter cells after cell division and for cell wall integrity. Required for host cell invasion and intracellular survival in host macrophages. Monomer. Interacts with RpfB and PBP1A (ponA1) via residues 448-472 of RipA, interacts with RpfE.

EXTERNAL LINKS

uniprot
enzyme classification

ripA

Peptidoglycan endopeptidase RipA

ripA

Molecular Synopsis