FEATURES

FAMILY

DESCRIPTION

Also known as FAA32_MYCTU, fadD32. Involved in the biosynthesis of mycolic acids (PubMed:19436070, PubMed:19477415). Catalyzes the activation of long-chain fatty acids as acyl-adenylates (acyl-AMP), which are then transferred to the phosphopantetheine arm of the polyketide synthase Pks13 for further chain extension (PubMed:15042094, PubMed:19436070, PubMed:19477415, PubMed:27547819, PubMed:27590338). Can use dodecanoate (C12), tetradecanoate (C14) and hexadecanoate (C16) (PubMed:19182784, PubMed:19436070, PubMed:19477415, PubMed:23364516, PubMed:26900152, PubMed:27590338). In vitro, displays a preference for long-chain over medium and short-chain fatty acid substrates (PubMed:19477415). Monomer in solution.

EXTERNAL LINKS

fadD32

Mutations

Mutation(s) distribution

Mutations table