FEATURES

FAMILY

DESCRIPTION

Also known as TPMT_MOUSE, Tpmt. Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (also called mercaptopurine, 6-MP or its brand name Purinethol) using S-adenosyl-L-methionine as the methyl donor (PubMed:18484748). TPMT activity modulates the cytotoxic effects of thiopurine prodrugs. A natural substrate for this enzyme has yet to be identified. Monomer.

EXTERNAL LINKS

uniprot
enzyme classification

Tpmt

Thiopurine S-methyltransferase

Mutations

Mutation(s) distribution

Mutations table

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