FEATURES

FAMILY

DESCRIPTION

Also known as TTUA_PYRHO, ttuA. Catalyzes the ATP-dependent 2-thiolation of 5-methyluridine residue at position 54 in the T loop of tRNAs, leading to 5-methyl-2-thiouridine (m(5)s(2)U or s(2)T) (PubMed:28655838). This modification allows thermal stabilization of tRNAs in thermophilic microorganisms, and is required for cell growth at high temperatures (By similarity). Can use free sulfide as sulfur source in vitro, which may be also the sulfur source in vivo (PubMed:28655838). Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification

ttuA

tRNA-5-methyluridine(54) 2-sulfurtransferase

ttuA

Molecular Synopsis