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FEATURES

FAMILY

DPH1/DPH2 family

DESCRIPTION

Also known as DPH2_PYRHO, dph2. Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Homodimer.

Also known as DPH2_PYRHO, dph2. Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of ...

EXTERNAL LINKS

uniprot
enzyme classification

dph2

2-(3-amino-3-carboxypropyl)histidine synthase

Molecular Synopsis

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