FEATURES

FAMILY

DESCRIPTION

Also known as IXTPA_PYRHO, PH1917. Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification

PH1917

Mutations

Mutation(s) distribution

Mutations table