FEATURES

FAMILY

DESCRIPTION

Also known as 3BP5_HUMAN, SH3BP5, SAB. Functions as guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25 (PubMed:26506309, PubMed:30217979). Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death. Interacts with BTK (PubMed:9571151, PubMed:10339589). Interacts with all isoforms of MAPK8, MAPK9, MAPK10 and MAPK12 (PubMed:12167088). Interacts with GDP-bound and nucleotide-free forms of RAB11A (PubMed:26506309, PubMed:30217979).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

SH3BP5

SH3 domain-binding protein 5

SH3BP5

Molecular Synopsis