FEATURES

FAMILY

UDP-glucose/GDP-mannose dehydrogenase family

DESCRIPTION

Also known as UGDH_HUMAN, UGDH. Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans (PubMed:21961565, PubMed:21502315, PubMed:23106432, PubMed:22123821, PubMed:25478983, PubMed:27966912, PubMed:30420606, PubMed:30457329). Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Required for embryonic development via its role in the biosynthesis of glycosaminoglycans (By similarity). Required for proper brain and neuronal development (PubMed:32001716). Homohexamer.

Also known as UGDH_HUMAN, UGDH. Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans (PubMed:21961565, PubMed:21502315, PubMed:23106432, PubMed:22123821 ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

UGDH

UDP-glucose 6-dehydrogenase

UGDH

Molecular Synopsis