FEATURES

FAMILY

DESCRIPTION

Also known as HPGDS_HUMAN, HPGDS, GSTS, PGDS, PTGDS2. Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide. Homodimer.

Also known as HPGDS_HUMAN, HPGDS, GSTS, PGDS, PTGDS2. Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

HPGDS

Mutations

Mutation(s) distribution

Mutations table