FEATURES

DESCRIPTION

Also known as IF2P_HUMAN, EIF5B, IF2, KIAA0741. Plays a role in translation initiation. Translational GTPase that catalyzes the joining of the 40S and 60S subunits to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon. GTP binding and hydrolysis induces conformational changes in the enzyme that renders it active for productive interactions with the ribosome. The release of the enzyme after formation of the initiation complex is a prerequisite to form elongation-competent ribosomes. Interacts with ANXA5 in a calcium and phospholipid-dependent manner.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

EIF5B

Eukaryotic translation initiation factor 5B

EIF5B

Molecular Synopsis