FEATURES

FAMILY

DESCRIPTION

Also known as ACX12_CAEEL, acox-1.2, acox-2. Involved in the first step of peroxisomal beta-oxidation by catalyzing the desaturation of fatty acid-derived side chains of ascaroside pheromones, which regulates development and behavior (PubMed:25775534, PubMed:27551084). Specifically, shortens ascarosides with 5-carbon omega side chain (asc-omega-C5) (PubMed:25775534, PubMed:27551084). Does not shorten indol-3-carbonyl(IC)-ascaroside with 7-carbon or 9-carbon side chains (PubMed:29863473). Does not catalyze the desaturation of fatty acids or hydroxylated fatty acids (PubMed:25775534, PubMed:27551084). Homodimer (Probable) (PubMed:27551084). Forms a heterodimer with acox-1.1 (PubMed:25775534).

EXTERNAL LINKS

acox-1.2

Mutations

Mutation(s) distribution

Mutations table