FEATURES

DESCRIPTION

Also known as HEXA_MICLU, hexs-a. Catalyzes the condensation of three molecules of isopentenyl diphosphate with farnesyl diphosphate (FPP) to yield (all-E)-hexaprenyl diphosphate (HexPP; C30), the precursor of the prenyl side chain of menaquinone-6. Large subunit Hexs-B catalyzes the condensation reaction and the final product chain length is cooperatively regulated by both the Hexs-A and Hexs-B subunits using the whole size of the hydrophobic cleft as a ruler. Dimer of heterodimer or heterotetramer composed of a small (Hexs-a) and large (Hexs-B) subunit.

EXTERNAL LINKS

uniprot
enzyme classification

hexs-a

Hexaprenyl-diphosphate synthase small subunit ((2E, 6E)-farnesyl-diphosphate specific)

hexs-a

Molecular Synopsis