FEATURES

FAMILY

DESCRIPTION

Also known as HCHL_PSEFL, HCHL. Catalyzes the hydration of the acyl-CoA thioester of ferulic acid and the subsequent retro-aldol cleavage of the hydrated intermediate to yield vanillin (4-hydroxy-3-methoxy-benzaldehyde) (PubMed:9461612, PubMed:10222033). The enzyme is also active with caffeoyl-CoA and 4-coumaroyl-CoA producing 3, 4-dihydroxybenzaldehyde and 4-hydroxybenaldehyde, respectively (PubMed:10222033). Homohexamer; dimer of trimers.

EXTERNAL LINKS

uniprot
enzyme classification

HCHL

Hydroxycinnamoyl-CoA hydratase-lyase

Mutations

Mutation(s) distribution

Mutations table

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