FEATURES

DESCRIPTION

Also known as MMI1_SCHPO, mmi1. RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs (By similarity). Functions alone and as part of the erh1-mmi1 complex, to recruit the CCR4-NOT complex and the NURS complex to target RNAs (PubMed:26942678, PubMed:30651569, PubMed:31974447). Suppresses the meiotic program during vegetative growth and promotes the meiotic program during mating (PubMed:31974447). Binds to DSR (determinant of selective removal) regions in meiotic mRNA, and recruits the NURS complex to targets (PubMed:16823445, PubMed:26942678). Recruitment of NURS complex to target mRNAs promotes mRNA decay by engagement of the nuclear exosome, and formation of heterochromatin islands at meiotic genes silenced by the exosome (PubMed:16823445, PubMed:26942678). Recruitment of the CCR4-NOT complex to target RNAs promotes heterochromatin formation at RNAi-dependent heterochromatin domains (HOODs), including a subset of meiotic genes, lncRNAs and retrotransposons (PubMed:26942678). Recruitment of the CCR4-NOT complex to rDNA promotes rDNA heterochromatin assembly (PubMed:26942678). Promotes non-canonical transcription termination at meiotic genes and prevents lncRNA transcription from invading and repressing adjacent genes (PubMed:16823445, PubMed:30651569). Component of the erh1-mmi1 complex composed of mmi1 and erh1 (PubMed:26942678, PubMed:31974447, PubMed:30651569). Interacts (via N-terminus) with erh1 in a 2:2 stoichiometry (PubMed:26942678, PubMed:31974447, PubMed:30651569). Interacts with rrp6 (PubMed:16823445).

EXTERNAL LINKS

mmi1

RNA binding exosome specificity factor Mmi1

mmi1

Molecular Synopsis