FEATURES

FAMILY

DESCRIPTION

Also known as ICOSL_HUMAN, ICOSLG, B7H2, B7RP1, ICOSL, KIAA0653. Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (By similarity). Interacts with CTLA4 (in vitro).

Also known as ICOSL_HUMAN, ICOSLG, B7H2, B7RP1, ICOSL, KIAA0653. Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine se ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ICOSLG

Mutations

Mutation(s) distribution

Mutations table