FEATURES

FAMILY

DESCRIPTION

Also known as FCN3_HUMAN, FCN3, FCNH, HAKA1. May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Has affinity with GalNAc, GlcNAc, D-fucose, as mono/oligosaccharide and lipopolysaccharides from S.typhimurium and S.minnesota. Homotrimer (PubMed:17215869). May form an octadecamer consisting of an elementary trimer unit. Does not interact with fibronectin, elastin or zymosan. Interacts with MASP1 and MASP2.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

FCN3

Ficolin-3

FCN3

Molecular Synopsis