FEATURES

FAMILY

DESCRIPTION

Also known as PPM1B_HUMAN, PPM1B, PP2CB. Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. Monomer (By similarity). Interacts with PAK6. Interacts with the phosphorylated form of IKBKB/IKKB.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PPM1B

Mutations

Mutation(s) distribution

Mutations table