FEATURES

FAMILY

DESCRIPTION

Also known as PR15A_HUMAN, PPP1R15A, GADD34. Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15'. Interacts with PCNA (By similarity). Interacts with LYN and KMT2A/MLL1. Interacts with PP1, PPP1R1A and SMARCB1. Interacts with SMAD7. Interacts with BAG1.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PPP1R15A

Protein phosphatase 1 regulatory subunit 15A

PPP1R15A

Molecular Synopsis