FEATURES

FAMILY

DESCRIPTION

Also known as ST1C4_HUMAN, SULT1C4, SULT1C2. Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic compounds. Can also sulfonate estrogenic compounds, however, the dietary flavonoids (phytoestrogen) and environmental estrogens, like bisphenol A are better substrates than 17beta-estradiol (E2) (PubMed:17425406, PubMed:28222028, PubMed:9852044, PubMed:26948952). Mediates the sulfation of doxorubicin and its analog epirubicin, two antitumor anthracyclines (PubMed:26948952).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

SULT1C4

Sulfotransferase 1C4

SULT1C4

Molecular Synopsis